Working at CDR-Life

CDR-Life is developing tumor-targeted immunotherapies to address unsolved problems in oncology by applying our LocATE antibody technology. To achieve our ambitious goals, we have created a dynamic working environment where we value curiosity, innovative thinking, committed teamwork, and the motivation to make an impact. We believe in trust and openness when doing our jobs, which may at times, take us beyond our comfort zones. 

CDR-Life is a young biotech company giving our employees the opportunity to grow in their roles and have a direct impact on the development of novel therapies for people in urgent need. We are building a highly diverse team that collaborates across functions with a strong project focus and a flat hierarchy.

If this sounds inspiring, check out our job openings or send us an unsolicited application at job@cdr-life.com

Current job openings:

Affinity Characterization Expert (100%)

Implementing methods for advanced affinity characterization of first-in-class antibodies

CDR-Life is a young and innovative biotech company based in Schlieren where we create novel, multi-specific therapeutic antibody fragments with non-standard biophysical characteristics. The Developability Group is responsible for assessing a wide range of biophysical properties of all engineered molecules to help select the strongest drug candidates. The group, with its specialized analytical methods, builds a bridge and works in very close collaboration with the Protein Discovery Group and the Technical Development Unit.

To strengthen our Developability Group, we are looking for a highly motivated and collaborative Affinity Characterization Expert. The successful candidate will be responsible for the affinity characterization of multi-specific therapeutic antibodies using state-of-the art technologies such as SPR and kinetic exclusion assays. The nature of multi-specific antibodies comes with a high degree of complexity in method development, including binding avidity and simultaneous binding of different targets. In addition, assessing the affinity of the antibody constructs towards their antigens on intact cells will be a part of this role.

Responsibilities

  • Independently develop affinity characterization methods and protocols.
  • Plan and execute affinity measurements.
  • Organize and maintain required equipment, consumables, and reagents.
  • Build up expertise in antibody binding properties and methods.
  • Support other biophysical characterization activities in the group.
  • Support the candidate selection process to select the best clinical candidates.
  • Ensure best practices of research, data management, and archiving.
  • Work collaboratively to achieve project goals.

Your Profile

  • Higher degree in Biochemistry, Biology or a related discipline.
  • Demonstrated expertise in antibody affinity characterization and method development for SPR technologies.
  • Experience from the pharmaceutical industry with focus on biophysical characterization of proteins and developability assessment / candidate selection process.
  • Strong interest in analytical methods and instruments.
  • Hands-on experience on HPLC is a plus.
  • Experience with bi-/multi-specific antibodies is a plus.
  • Work effectively in teams, data driven problem solver.
  • Fluency in written and spoken English.

To apply or in case of questions, please contact Philipp Richle, Developability Leader: philipp.richle@cdr-life.com. We are looking forward to hearing from you.

Antibody Engineer (100%)

Design and optimize therapeutic antibodies to discover first-in-class biologics.

CDR-Life is a young and innovative biotech company based in Schlieren where we create novel antibody therapies against incurable diseases. A key part of this process is driven by the Discovery Group that designs, produces, and optimizes new antibodies in a variety of formats for the development of promising new drug candidates.

As Antibody Engineer, you will play an important role in the design and optimization of antibodies and antibody derived molecules and collaborate with colleagues to deliver first-in-class biologics. In addition, you will help to drive innovative approaches for drug discovery using novel antibody and protein engineering technologies. We are looking for a highly motivated and collaborative individual with a passion for drug discovery research, who enjoys working in a fast-paced and highly dynamic working environment.

Responsibilities

  • Plan and execute molecular cloning activities.
  • Lead/support phage display antibody library generation, and selection.
  • Lead/support antibody screening campaigns.
  • Lead/support activities for the design and optimization of antibody candidates.
  • Ensure best practices of research, data management, and archiving.
  • Proactively prepare and/or organize required equipment, consumables, and reagents.

Your Profile

  • BS, MSc. or equivalent in Biology, Biochemistry, or a related discipline.
  • Demonstrated expertise in molecular biology techniques is essential.
  • Experience in the pharmaceutical industry with focus on antibody screening and/or protein engineering.
  • Experience with bi-/multispecific antibody design would be a plus.
  • Experience with antibody affinity maturation and antibody humanization would be a plus.
  • Experience with antibody display techniques (phage, yeast or others) would be a plus.
  • Ability to work independently in a team environment.
  • Positive and proactive attitude.

To apply or in case of questions, please contact Fabian Scheifele, Discovery Leader: fabian.scheifele@cdr-life.com. We are looking forward to hearing from you.